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Authors: Matthias Kahm, Guido Hasenbrink, Hella Lichtenberg-Fraté, Jost Ludwig, Maik Kschischo
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grofit: Fitting Biological Growth Curves with R
Reference: Vol. 33, Issue 7, Feb 2010
Submitted 2008-07-14, Accepted 2009-06-18
Type: Article
Abstract:

The grofit package was developed to fit many growth curves obtained under different conditions in order to derive a conclusive dose-response curve, for instance for a compound that potentially affects growth. grofit fits data to different parametric models and in addition provides a model free spline method to circumvent systematic errors that might occur within application of parametric methods. This amendment increases the reliability of the characteristic parameters (e.g.,lag phase, maximal growth rate, stationary phase) derived from a single growth curve. By relating obtained parameters to the respective condition (e.g.,concentration of a compound) a dose response curve can be derived that enables the calculation of descriptive pharma-/toxicological values like half maximum effective concentration (EC50). Bootstrap and cross-validation techniques are used for estimating confidence intervals of all derived parameters.

Paper: [download]
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grofit: Fitting Biological Growth Curves with R
(application/pdf, 676.5 KB)
Supplements: [download]
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grofit_1.0.tar.gz: R source package
(application/x-gzip, 562.1 KB)
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v33i07.R: R example code from the paper
(application/octet-stream, 2.4 KB)
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Creative Commons License
This work is licensed under the licenses
Paper: Creative Commons Attribution 3.0 Unported License
Code: GNU General Public License (at least one of version 2 or version 3)
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