Published by the Foundation for Open Access Statistics Editors-in-chief: Bettina Grün, Torsten Hothorn, Rebecca Killick, Edzer Pebesma, Achim Zeileis    ISSN 1548-7660; CODEN JSSOBK
Authors: Karline Soetaert, Thomas Petzoldt
Title: Inverse Modelling, Sensitivity and Monte Carlo Analysis in R Using Package FME
Abstract: Mathematical simulation models are commonly applied to analyze experimental or environmental data and eventually to acquire predictive capabilities. Typically these models depend on poorly defined, unmeasurable parameters that need to be given a value. Fitting a model to data, so-called inverse modelling, is often the sole way of finding reasonable values for these parameters. There are many challenges involved in inverse model applications, e.g., the existence of non-identifiable parameters, the estimation of parameter uncertainties and the quantification of the implications of these uncertainties on model predictions.

The R package FME is a modeling package designed to confront a mathematical model with data. It includes algorithms for sensitivity and Monte Carlo analysis, parameter identifiability, model fitting and provides a Markov-chain based method to estimate parameter confidence intervals. Although its main focus is on mathematical systems that consist of differential equations, FME can deal with other types of models. In this paper, FME is applied to a model describing the dynamics of the HIV virus.

Page views:: 14427. Submitted: 2009-09-22. Published: 2010-02-02.
Paper: Inverse Modelling, Sensitivity and Monte Carlo Analysis in R Using Package FME     Download PDF (Downloads: 13041)
FME_1.1.tar.gz: R source package Download (Downloads: 1352; 2MB)
v33i03.R: R example code from the paper Download (Downloads: 1676; 5KB)

DOI: 10.18637/jss.v033.i03

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Paper: Creative Commons Attribution 3.0 Unported License
Code: GNU General Public License (at least one of version 2 or version 3) or a GPL-compatible license.