Published by the Foundation for Open Access Statistics Editors-in-chief: Bettina Grün, Torsten Hothorn, Rebecca Killick, Edzer Pebesma, Achim Zeileis    ISSN 1548-7660; CODEN JSSOBK
Authors: Jörg Polzehl, Karsten Tabelow
Title: Beyond the Gaussian Model in Diffusion-Weighted Imaging: The Package dti
Abstract: Diffusion weighted imaging (DWI) is a magnetic resonance (MR) based method to investigate water diffusion in tissue like the human brain. Inference focuses on integral properties of the tissue microstructure. The acquired data are usually modeled using the diffusion tensor model, a three-dimensional Gaussian model for the diffusion process. Since the homogeneity assumption behind this model is not valid in large portion of the brain voxel more sophisticated approaches have been developed.
This paper describes the R package dti. The package offers capabilities for the analysis of diffusion weighted MR experiments. Here, we focus on recent extensions of the package, for example models for high angular resolution diffusion weighted imaging (HARDI) data, including Q-ball imaging and tensor mixture models, and fiber tracking. We provide a detailed description of the package structure and functionality. Examples are used to guide the reader through a typical analysis using the package. Data sets and R scripts used are available as electronic supplements.

Page views:: 4816. Submitted: 2010-11-10. Published: 2011-10-31.
Paper: Beyond the Gaussian Model in Diffusion-Weighted Imaging: The Package dti     Download PDF (Downloads: 4356)
dti_0.9-6.3.tar.gz: R source package Download (Downloads: 839; 482KB)
v44i12.R: R example code from the paper Download (Downloads: 867; 8KB) Data files Download (Downloads: 835; 44MB)

DOI: 10.18637/jss.v044.i12

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Paper: Creative Commons Attribution 3.0 Unported License
Code: GNU General Public License (at least one of version 2 or version 3) or a GPL-compatible license.