Published by the Foundation for Open Access Statistics Editors-in-chief: Bettina Grün, Torsten Hothorn, Rebecca Killick, Edzer Pebesma, Achim Zeileis    ISSN 1548-7660; CODEN JSSOBK
Authors: Jan Graffelman
Title: Exploring Diallelic Genetic Markers: The HardyWeinberg Package
Abstract: Testing genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg package offers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under equilibrium and disequilibrium. Functions for testing equilibrium in the presence of missing data by using multiple imputation are provided. The package also supplies various graphical tools such as ternary plots with acceptance regions, log-ratio plots and Q-Q plots for exploring the equilibrium status of a large set of diallelic markers. Classical tests for equilibrium and graphical representations for diallelic marker data are reviewed. Several data sets illustrate the use of the package.

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Paper: Exploring Diallelic Genetic Markers: The HardyWeinberg Package     Download PDF (Downloads: 1868)
HardyWeinberg_1.5.5.tar.gz: R source package Download (Downloads: 212; 796KB)
v64i03.R: R example code from the paper Download (Downloads: 248; 2KB)

DOI: 10.18637/jss.v064.i03

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Paper: Creative Commons Attribution 3.0 Unported License
Code: GNU General Public License (at least one of version 2 or version 3) or a GPL-compatible license.