randomizeR: An R Package for the Assessment and Implementation of Randomization in Clinical Trials

Diane Uschner, David Schindler, Ralf-Dieter Hilgers, Nicole Heussen

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Randomization in clinical trials is the key design technique to ensure the comparability of treatment groups. Although there exist a large number of software products which assist the researcher to implement randomization, no tool which would cover a wide range of procedures and allow the comparative evaluation of the procedures under practical restrictions has been proposed in the literature so far. The R package randomizeR addresses this need. The paper includes a detailed description of the randomizeR package that serves as a tutorial for the generation of randomization sequences and the assessment of randomization procedures.

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