Published by the Foundation for Open Access Statistics Editors-in-chief: Bettina Grün, Torsten Hothorn, Rebecca Killick, Edzer Pebesma, Achim Zeileis    ISSN 1548-7660; CODEN JSSOBK
Authors: Nicolas R. Lauve, Stuart J. Nelson, S. Stanley Young, Robert L. Obenchain, Christophe G. Lambert
Title: LocalControl: An R Package for Comparative Safety and Effectiveness Research
Abstract: The LocalControl R package implements novel approaches to address biases and confounding when comparing treatments or exposures in observational studies of outcomes. While designed and appropriate for use in comparative safety and effectiveness research involving medicine and the life sciences, the package can be used in other situations involving outcomes with multiple confounders. LocalControl is an open-source tool for researchers whose aim is to generate high quality evidence using observational data. The package implements a family of methods for non-parametric bias correction when comparing treatments in observational studies, including survival analysis settings, where competing risks and/or censoring may be present. The approach extends to bias-corrected personalized predictions of treatment outcome differences, and analysis of heterogeneity of treatment effect-sizes across patient subgroups.

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Paper: LocalControl: An R Package for Comparative Safety and Effectiveness Research     Download PDF (Downloads: 340)
LocalControl_1.1.2.2.tar.gz: R source package Download (Downloads: 25; 2MB) Replication materials Download (Downloads: 21; 687KB)

DOI: 10.18637/jss.v096.i04

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Paper: Creative Commons Attribution 3.0 Unported License
Code: GNU General Public License (at least one of version 2 or version 3) or a GPL-compatible license.