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The R package skpr provides a suite of functions to generate and evaluate experimental designs. Package skpr generates D, I, Alias, A, E, T, and G-optimal designs, and supports custom user-defined optimality criteria, N-level split-plot designs, mixture designs, and design augmentation. Also included are a collection of analytic and Monte Carlo power evaluation functions for normal, non-normal, random effects, and survival models, as well as tools to plot fraction of design space plots and correlation maps. Additionally, skpr includes a flexible framework for the user to perform custom power analyses with external libraries and user-defined functions, as well as a graphical user interface that wraps most of the functionality of the package in a point-and-click web application.